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Hassan Malakuti

Hassan Malakuti

Mashhad University of Medical Sciences, Mashhad, Iran.

Title: A Cohort Study on the cervical precancerous lesion demographic character, prevalence and Practice onits association with Human Papillomavirus Virus subtypes between Iranian populations

Biography

Biography: Hassan Malakuti

Abstract

Retrospective study has reported that cervical cancer is the most common gynecologic malignancy around the world. At the first sight, based on the long-time interval between the pre-cancerous phase and this malignantprogression,and the simple available screening test,in the other hand the well-known correlation between cervical lesion (mainly squamous cell subtype) andhuman papillomavirus, its prevention seems to be simply achieved. Despite all of this concept near 270000 woman's death per year is due to this malignancy.

Cervical cancer prevalence in developing countries is increasing. Epidemiology, prevalence, clinical feature, risk factor and the validity of Guideline based screening approach in our country hadn’t studied in a large prospective study before.

 This study aimed to assess the demographic data on Human papillomavirus infected patient and the reliability of the present screening test, and to establish any correlation between the sub type of human papilloma virus(HPV) and cervical lesion progression among Iranian woman in Mashhad.

Methods

This cohort study was conducted on 562 patients with cervical intraepithelial neoplasiaand cancer,who was referred to the Gynecology Clinic at Ghaem Hospital-Iran- Mashhad from Nov2016 to Feb 2018. All patients demographic, familial, nutritional, clinical feature, previous screening (consist of Pap smear and HPV typing test) and diagnostic test (colposcopic biopsy samples) results were collected and analysis by SPSS. All the participant were follow up for assessing the progression strength of each HPV subtype during the time. The HPV infected patients were divided into 5 subgroups: HPV16/18, other high risk HPV, HPV 6/11, other low risk HPV, coexistence of high and low risk HPV cases.